yjYing-Jung Chen, PhD, Assistant Professor

● Teaching Courses

Undergraduate school:
1. Biotechnology
2.Laboratory in Fragrance and Cosmetics Formulation
Graduate school:
1. Special Topics on Biotechnology

● The Highest Education Degree 

Ph. D. in Institute of Biomedical Science, National Sun Yat-Sen University

● Personal Experiences

2017/02~present, Assistant Professor, Department of Fragrance and Cosmetic Science, Kaohsiung Medical University

2014/08-2017/01, Post-Doctoral Fellow in Institute of Biomedical Science, National Sun Yat-Sen University

● E-mail
yjchen@cc.kmu.edu.tw

● TEL:07-3121101 ext.2804
FAX:07-3210683

● Research Area

Intracellular signaling pathways, Epigenetics regulation, Applications of nanoparticles in biology and medicine

● Recent Publications

2013 ~ present

1. Shi, Y. J., Chen, Y. J., Hu, W. P., Chang, L. S. (2017) Detection of Naja atra cardiotoxin using adenosine-based molecular beacon. Toxins (Basel), 9(1), 24-36.

2. Lee, Y. C., Chen, Y. J., Huang, C. H., Chang, L. S. (2016) Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis, 1-15.

3. Chen, Y. J., Lee, Y. C., Huang, C. H., Chang, L. S. (2016) Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFkB/c-Jun activation in breast cancer MDA-MB-231. Toxicol Appl Pharmacol., 310, 98-107.

4. Chen, Y. J., Liu, W. H., Chang, L. S. (2016) Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells. Arch Toxicol., 1-15.

5. Chen, Y. J.*, Lin, K. N.*, Jhang, L. M., Huang, C. H., Lee, Y. C., Chang, L. S. (2016). Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells. Chem Biol Interact., 252, 131-140. *Chen, Y. J. and Lin, K. N. equally contribute to this work.

6. Chen, Y. J., Tsai, C. Y., Hu, W. P., Chang, L. S. (2016). DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins. Toxins, 8(3), 66.

 7. Huang, C. H.*, Chen, Y. J.*, Chao, T. Y.*, Liu, W. H., Changchien, J. J., Hu, W. P., Chang, L. S. (2016) The Association Between p38 MAPK‐Mediated TNF‐a/TNFR2 up‐Regulation and 2‐(4‐‐7‐Methoxybenzothiazole‐Induced Apoptosis in Human Leukemia U937 Cells. J Cell Physiol., 231(1), 130-141. *Huang, C. H. Chen, Y. J. and Chao, T. Y. equally contribute to this work.

 8. Chen, Y. J., Chang, L. S. (2015) NFkB-and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-a-treated human leukemia U937 cells. Biochim Biophys Acta., 1849(10), 1248-1259.

9. Tsai, C. Y., Chen, Y. J., Fu, Y. S., Chang, L. S. (2015) Antibacterial and membrane-damaging activities of mannosylated bovine serum albumin. Arch Biochem Biophys., 573, 14-22.

10. Changchien, J. J.*, Chen, Y. J.*, Huang, C. H., Cheng, T. L., Lin, S. R., Chang, L. S. (2015) Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression. Toxicol Appl Pharmacol., 284(1), 33-41. *Changchien, J. J. and Chen, Y. J. equally contribute to this work.

11. Yang, S. Y.*, Chen, Y. J.*, Kao, P. H., Chang, L. S. (2014) Bovine serum albumin with glycated carboxyl groups shows membrane-perturbing activities. Arch Biochem Biophys., 564, 43-51. *Yang, S. Y. and Chen, Y. J. equally contribute to this work.

12. Chen, Y. J., Chang, L. S. (2014) Simvastatin induces NFkB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells. Biochem Pharmacol., 92(4), 530-543.

13. Liu, W. H.*, Chen, Y. J.*, Chien, J. H.*, Chang, L. S. (2014) Amsacrine suppresses matrix metalloproteinase‐2 (MMP‐2)/MMP‐9 expression in human leukemia cells. J Cell Physiol., 229(5), 588-598. *Liu, W. H., Chen, Y. J. and Chien, J. H. contributed equally to this work.

14. Liu, W. H.*, Chen, Y. J.*, Cheng, T. L., Lin, S. R., Chang, L. S. (2013) Cross talk between p38 MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit a and MAPK phosphatase-1 expression in human leukemia U937 cells. Cell Signal., 25(9), 1845-1851. *Liu, W. H. and Chen, Y. J. contributed equally to this work.

15. Chen, Y. J., Chang, L. S. (2013) Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-a production in human leukemia cells with expressed Bcr/Abl. Biochem Pharmacol., 86(5), 620-631.

16. Kao, P. H., Chen, Y. J., Yang, S. Y., Lin, S. R., Hu, W. P., Chang, L. S. (2013) Fusogenicity of Naja naja atra cardiotoxin-like basic protein on sphingomyelin vesicles containing oxidized phosphatidylcholine and cholesterol. J Biochem., 153(6), 523-533.

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